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CONCLUSION These data suggest that AN is accompanied by a state of brain hyperarousal with abnormal reactivity to environmental stimuli, similar to the state of HS after musical stimulation. If confirmed, this finding may have treatment implications. LEVEL OF EVIDENCE III, Evidence obtained from well-designed cohort or case-control analytic studies.BACKGROUND This study aimed to analyze our 11-year experience using NSM with immediate breast reconstruction in breast cancer. METHODS Between January 2007 and December 2015, 251 NSMs were per