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tion in marine ecosystems and provide new insights for a better understanding of the ecological recovery of historically contaminated marine environments. This study investigated the role of the feeding regime on cellular (lysosomal membrane impairment), oxidative (superoxides and nitric oxides generation, as well as lipid peroxidation) and genotoxic (nuclear abnormalities) biomarkers measured in hemocytes of mussels Mytilus galloprovincialis treated with diclofenac (DCF). Specifically, unfed mussels, or mussels fed ad libitum with alg