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The underyling spectral range of pathology is complex and creates a challenge for targeted molecular treatments. We here tested the hypothesis that leukotrienes are involved in the pathology of DLB and that preventing leukotrienes through Montelukast, a leukotriene receptor antagonist and approved anti-asthmatic medicine, might relieve pathology and restore cognitive functions. Appearance of 5-lipoxygenase, the rate-limiting enzyme for leukotriene production, had been certainly raised in brains with DLB.