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29 ± 0.10 μmol/L) with high selectivity for AChE over BChE (selectivity ratio 27.96). An enzyme kinetic study of compound 5a suggests that it produces a mixed-type inhibitory effect against AChE. To examine the risk of incident type 2 diabetes mellitus (DM) among patients with rheumatoid arthritis (RA) versus the risk among 4 different comparison cohorts. Using a large US commercial insurance database, Optum Clinformatics Data Mart (2005-2017), we identified patients with RA based on ≥2 diagnoses for RA and use of ≥1 disease-modifying a
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