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Prenatal HI also increased the vasoconstrictor response to norepinephrine, the media thickness, collagen deposition, and the oxidative damage in the aorta from adult male offspring compared to control and sham groups. Our results suggest an association among prenatal HI and adult vascular structural and functional changes, oxidative stress damage, and depressive behavior. A cluster of aortic bioprosthetic valve failures, most of which were Trifecta bioprostheses, was observed in our institution. This study was performed to assess if th
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