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The current research investigated the result of betaine therefore the role of nuclear factor-erythroid-2-related element 2 (Nrf2) and heme oxygenase-1 (HO-1) genetics in hepatotoxicity caused by APAP in mice. In this study, male Naval Medical Research Institute (NMRI) mice had been treated with 500 mg/kg of betaine for 5 times accompanied with an individual dose of APAP 300 mg/kg regarding the fifth day. Biochemical, histological, immunohistochemical, Western blot, and real time polymerase chain respon
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