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004) if they had negative lymph nodes (LNs). For patients positive LNs, the OS was significantly different between the chemotherapy group and the non-chemotherapy group when the tumors were larger than 1cm(T=1-2.9cm, p=0.006; T>3cm, p=0.049, respectively). Adjuvant chemotherapy maybe improves prognosis in patients with negative LNs and tumors larger than 3cm, or patients with LNs metastasis and tumors larger than 1cm. We suggest considering clinical characteristics meanwhile when deciding chemotherapy or not. Randomized controlled trials (RCT) are e