https://amg925inhibitor.com/co....ronary-thrombosis-as
Right here, we show that tristetraprolin (TTP), an mRNA-binding necessary protein, can modulate the replication stress reaction via stabilization of Claspin mRNA. TTP depletion compromised specifically within the phosphorylation of CHK1, not p53 or H2AX among various other ATR substrates, and produced CHK1-defective replication phenotypes including accumulation of stalled replication forks. Significantly, the phrase of siRNA-resistant TTP in TTP-
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