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Subjects with different HLA alleles, EBNA-1, and IM status were contrasted regarding MS threat by determining odds ratios (OR) with 95% confidence intervals (CI) employing logistic regression. Causal mediation analysis had been used to assess as to what extent the relationship between IM history and MS danger was mediated by high anti-EBNA-1 antibody amounts and the other way around. Results The causal mediation analysis revealed that both aspects of EBV infection mainly act right on M
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