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This review focuses on the role of the NLRP3 inflammasome in the pathophysiology of PE. Copyright © 2020 Shirasuna, Karasawa and Takahashi.Objective Automated seizure detection is a key aspect of wearable seizure warning systems. As a result, the quality of life of refractory epilepsy patients could be improved. Most state-of-the-art algorithms for heart rate-based seizure detection use a so-called patient-independent approach, which do not take into account patient-specific data during algorithm training. Although such s