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R-Co3O4 displays a considerably improved peroxidase-like activity in comparison with that exhibited by pristine Co3O4 (P-Co3O4). The catalytic procedure in case of R-Co3O4 takes place prior to the conventional Michaelis-Menten equation, plus the affinity of R-Co3O4 to H2O2 is evidently greater than that of P-Co3O4. Moreover, the thickness useful theory calculations unveiled that the development of air vacancies to R-Co3O4 improves its H2O2 adsorption ability and facilitates the decomp