IPP is an intermediate in the classical β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase pathway (commonly called the mevalonate pathway) and in the non-mevalonate (methylerythritol 4-phosphate) MEP pathway of isoprenoid precursor biosynthesis. IPP toxicity presents a challenge in engineered microbial systems since its formation is unavoidable in terpene biosynthesis.
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