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003), oral sex (P value=0.02) were found to be associated with HSV-2 acquisition in HIV patients. All other risk factors such as history of transactional sex, age at sexual debut and condom use were not significant. The results highlight the potential public health impact of HSV-2 particularly in a developing country like Nigeria where HSV-2 testing is not included in our testing and treatment protocol for HIV. This result should lead to commencement of HSV type-specific serological testing in the HIV infected population and also high r