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Future studies should focus on neural factors as well as muscular factors independent of atrophy (single fibre excitability and mechanical properties, architectural factors) and on the role of extracellular matrix changes. Bed rest results in non-uniform loss of isometric muscle strength and atrophy over time, where the magnitude of change was greater for muscle strength than for atrophy. Future research should focus on the loss of muscle function and the underlying mechanisms, which will aid in the development of countermeasures to mit

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