https://www.selleckchem.com/pr....oducts/butyzamide.ht
HFD-induced obesity was associated with a reduction of insulin-degrading enzyme, one of the main hepatic enzymes responsible for Aβ clearance. The hepatic rate of cerebrosterol glucuronidation was lower in obese 3xTg-AD than in nonobese controls (P less then 0.05) and higher compared with obese NTg (P less then 0.05), although circulating levels remained unchanged. Conclusion Modulation of hepatic lipids, Aβ, and cerebrosterol metabolism in obese 3xTg-AD mice differs from control mice. This study sheds light on the liver-brain axis,
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