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Bioinformatics analysis was carried out including unsupervised principal component analysis and supervised orthogonal projection to latent structure discriminant analysis for the differential metabolites between the two groups. The differential metabolites were followed-up for Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Results Compared with the control group, the body weight of the rats was significantly reduced (P 0.1). Conclusion Oral exposure to TiO2 NPs for 90 days could disrupt the metabolism of the intestine a
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