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To evaluate the dynamical interplay between perinatal leptin concentrations and neonatal weight evolution until 3 months of age. In a prospective observational study, maternal, cord blood and neonatal plasma leptin concentrations were correlated to birthweight and 3-month weight in 26 full-term, 20 preterm, and 17 intrauterine growth restriction (IUGR) mother-neonate couples. The median of maternal, cord blood, neonatal leptin concentrations were significantly different among the three groups ( = 0.010; 0.001; =0.041 correspondingl