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ADHD Treatment For Adults - Stimulant Medication Stimulant drugs like methylphenidate and dextroamphetamine have been regarded as the as the first-line treatment for adults with ADHD. These drugs regulate and boost levels of brain chemicals known as neurotransmitters. Nonstimulant medications such as atomoxetine and antidepressants may be prescribed when stimulants are not appropriate for the patient due to other health issues or adverse effects. These medications are more slow