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05). Correlation analysis indicated that association between AI and ESM-1 was negative ( 0.01), VEGF and ESM-1 was positive ( 0.01), and HGF and ESM-1 was positive ( 0.01). In stable COPD patients, we proved that ESM-1, VEGF and HGF were decreased significantly, while AI was increased ( 0.05). Correlation between AI and ESM-1 was negative ( 0.01), VEGF and ESM-1 was positive ( 0.01), and HGF and ESM-1 was positive ( 0.01). ESM-1 expression decreased and AI increased in emphysematous mice and stable COPD patien
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