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First Line Treatment For ADHD in Adults Some people with ADHD find medication helps to manage their symptoms. The stimulants like methylphenidate or amphetamine work by increasing brain activity in areas that control attention and behavior. Other medications, like the non-stimulant drug atomoxetine and antidepressants that work differently, but are still effective. Regular visits to the GP is recommended for patients who take medication. They can alter dosages and check f