https://www.selleckchem.com/pr....oducts/pf-03084014-p
These findings highlight the therapeutic potential of a glial-centric therapeutic strategy for diseases of hyperexcitability.The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms distinct from its canonical induction by the integrated stress response (ISR). However, its broader roles as a downstream target of mTORC1 are unknown.
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