https://www.selleckchem.com/pr....oducts/ly3214996.htm
Acute and sub-acute toxicity studies were conducted to evaluate the toxicity profile of compounds. Treatment with the thiazolidine derivative, 1b and 1d, attenuated carrageenan-induced thermal hyperalgesia and mechanical allodynia at doses of 1 mg/kg, 3 mg/kg, and 10 mg/kg. No motor coordination deficits were observed in animals. The compounds also reduced IL-1β expression in the spinal cord of mice. Acute and sub-acute toxicity studies revealed that both compounds were safe. The compounds exhibit promising activity against inflammato
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