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Conclusion This experiment indicated that OHE caused pain stress, oxidative stress, and reduction of total antioxidant power in female dogs. Finally, female dogs needed antioxidant for 7 days after OHE. Copyright © Sakundech, et al.Background and Aim The commercial formulations of the herbicide atrazine (cATZ) are widely employed in Brazilian agriculture, and, as a consequence, ATZ has been found at levels above that established by law in the river basins in Brazil. Although the toxicity of ATZ in fish is well documented,