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Modification of agents acting on the renin-angiotensin system on breast cancer risk was also observed for atenolol. The increased risk of breast cancer associates with the use of beta-1 selective blockers in a dose-response manner. Breast cancer surveillance is recommended for hypertensive female patients using beta-1 selective blockers. Breast cancer surveillance is recommended for hypertensive female patients using beta-1 selective blockers. In the United States, 45,000 adolescent and young adult (AYA) women are diagnosed with ca