https://www.selleckchem.com/pr....oducts/pf-06952229.h
Mechanistically, UBA1 inhibition disrupts global protein ubiquitination in GBM cells, thereby inducing ER stress and UPR. UPR activates the PERK/ATF4 and IRE1α/XBP signaling axes. These findings indicate that UBA1 inhibition could be an attractive strategy that may be potentially used in the treatment of patients with GBM, and GRP78 can be used as a molecular marker for personalized treatment by targeting UBA1.Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study,
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