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Patients that have attained really low low-density lipoprotein CH (LDL-C) levels in clinical tests have indicated the lowest cardio-vascular threat. The current medical guidelines set such a concentration for LDL-C as less then 1.4 mmol/L. Nevertheless, the question of minimum permissible target values of the lipids stays unresolved. A number of experimental and medical studies showed some bad consequences of reduced LDL-C levels At the same time, the present day arsenal of lipid reducing medicine