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Acute morphine caused antinociception as you expected, whereas intense M3G caused tactile allodynia, because did both persistent M3G and morphine. Chronic M3G additionally caused antinociceptive cross-tolerance to morphine. M3G and morphine enhanced substance P levels likewise when you look at the nociceptive laminae associated with spinal-cord. This study demonstrates that chronic intrathecal M3G sensitises animals to mechanical stimulation and elevates material P amounts in