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In this issue of JEM, Hong et al. (https//doi.org/10.1084/jem.2020014 identify a major step in the pathogenesis of cerebral cavernous malformations (CCMs), which at the same time offers insight into potential therapy for this disease.Heart failure (HF) is a chronic debilitating and potentially life-threatening condition. Heart Failure patients are usually at high risk of polypharmacy and consequently, potentially inappropriate prescribing leading to poor clinical outcomes. Based on the published literature, a comprehensive HF-specific
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