https://www.selleckchem.com/pr....oducts/baf312-siponi
The development and immune recognition of natural killer (NK) cell are regulated critically by major histocompatibility complex (MHC) class I molecules. However, it remains unclear whether the function of NK cells is regulated by MHC class II molecules. To test this, we monitored the development, phenotype and function of NK cells by using MHC class II deficient (H2-/-) mice. The numbers and development of NK cells keep unaltered in H2-/- mice, compared with those in wide type (H2+/+) mice. A part of Ly49 family receptors on NK