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Publications had been included if they supplied specific diligent degree data in connection with design of combined involvement. Descriptive statistics were used to close out results. OUTCOMES a complete of 4339 articles were screened, of which 67 had been included, encompassing 372 customers. Nearly all clients had metastatic melanoma (57%), and so they were treated with anti-PD1 or anti-PDL1 treatment (78%). Median time for you to onset of joint disease was 4 months (range, 1 day to 53 months). Forty-nine