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Ventilator-associated pneumonia is common and is treated using nebulized antibiotics. Although adequate pulmonary biodistribution is important for antibiotic effect, there is a lack of data for both intravenous (IV) and nebulized antibiotic administration during mechanical ventilation. To describe the comparative pulmonary regional distribution of IV and nebulized technetium-99m-labeled tobramycin ( Tc-tobramycin) 400 mg in a mechanically-ventilated ovine model. The study was performed in a mechanically-ventilated ovine model. Tc-tobram