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Thinking about the medical challenge that the treatment of DPN signifies, this study revealed for the first time, that the intrathecal cannabinoid receptors agonists may represent an alternate to treat DNP.Mu-opioid receptor (MOR) agonists are extremely efficacious to treat discomfort but have considerable abuse responsibility. Recently, we reported that nalfurafine, when coupled with oxycodone at a specific proportion, paid off the strengthening effects of oxycodone in rats whi

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