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diagrams at lower velocities V manifest a pronounced strength decrease over small distances, whereas they exhibit progressive increase in the shear stress at higher V, which is reminiscent of a transition from ductile behavior at high velocities to brittle response at low velocities.Theory predicts that self-sustained oscillations require robust delays and nonlinearities (ultrasensitivity). Delayed negative feedback loops with switch-like inhibition of transcription constitute the core of eukaryotic circadian clocks. The kinetics of core

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