https://www.selleckchem.com/pr....oducts/pf-562271.htm
Metabolic reprogramming is critical for the polarization and function of tumor associated macrophages (TAMs) and hepatocarcinogenesis, but how this reprogramming occurs is unknown. Here, we showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, is downregulated in hepatocellular carcinoma (HCC)-associated macrophages, which correlated with tumorigenesis and enhanced the accumulation and polarization of M2 TAM. Mechanistically, RIPK3 deficiency in TAMs reduced reactive oxygen species (ROS) and signi
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