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When BCL6 expression or task was reduced in these outlines, increased apoptosis and a profound lack of expansion was seen, in line with gene phrase signatures suggestive of anti-apoptotic and pro-survival signaling role for BCL6 in glioblastoma. Further, treatment aided by the standard therapies for glioblastoma-ionizing radiation and temozolomide-both induced BCL6 expression in vitro, and an in vivo orthotopic animal type of glioblastoma. Importantly, inhibition of BCL6 in conjunction with genotoxic treatme