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88, 95% CI 3.17-4.76, P less then 0.001], R62H (OR=1.37, 95% CI 1.11-1.70, P=0.004) and H157Y (OR=4.22, 95% CI 1.93-9.21, P less then 0.001). However, R62H only conferred a mild risk compared to R47H and H157Y (OR=1.37 vs. 3.88 and 4.22, respectively). D87N was not associated with AD susceptibility. Sensitivity analysis indicated that the association identified for R62H was not significant (P=0.192) when excluding a large-sample study. Subgroup analysis according to ethnicity revealed significant associations (R47H and H157Y) in Caucasi
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