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Having said that, the tested compounds were less toxic against typical renal epithelial cellular outlines (Vero cells). The in vitro enzyme inhibition assay of 8 displayed exemplary inhibitory task against Escherichia coli DNA B gyrase and moderate one against E. coli Topoisomerase IV (IC50 = 0.33 ± 1.25 and 19.72 ± 1.00 µM, correspondingly) in comparison with novobiocin (IC50 values 0.28 ± 1.45 and 10.65 ± 1.02 µM, respectively). Finally, the molecular docking had been done to
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