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Eligibility assessment was performed by two separate reviewers. Data had been abstracted by one reviewer which verified crucial entries at a moment time point. For unwanted effects reported by 3 scientific studies a pooled result estimate had been calculated, and heterogeneity assessed via I2; for outcomes reported by 5 researches effect modification by total day-to-day dosage (EMbyTDD; 600 mg/d) ended up being examined via m
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