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UNBIASED To report the end result of two patients with CLOVES syndrome addressed with oral rapamycin. CLINICAL PROBLEMS Case 1 A three-year-old female preschooler with CLOVES problem and reputation for repeated hospita lizations because of severe infections resulting from macrocystic lymphatic malformations and due to thrombotic symptoms. The client evolved with low quality of life, several hospitalizations, medical danger and development for the lesions, therefore, oral rapamyc
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