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According to the monogenic model, the number of genes involved to induce sulfoxaflor resistance revealed that sulfoxaflor resistance was polygenic in nature. The realized heritability (h ) value for sulfoxaflor resistance was 0.2. The synergists experiment indicated that esterases were involved in the sulfoxaflor resistance mechanism in DCB. The current results indicate that there is autosomal, incompletely dominant and polygenic inheritance of sulfoxaflor resistance in DCB. Our results would be helpful in delaying sulfoxaflor resistance