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These results demonstrate that CNP provide an effective treatment of CLI with excessive ROS by scavenging ROS to improve endothelial survival and by inducing Ref-1/APE1-dependent angiogenesis to revascularize an ischemic limb. The widespread use of the antibiotic ciprofloxacin (CIP) poses a serious risk to soil organisms. Here, earthworms (Eisenia fetida) were used to explore the effect of CIP exposure on growth, reproduction, mortality, antioxidant enzyme activity, DNA damage, and mRNA levels. The results showed that mortality, weight,

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