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ated with NAC, which can be applied to guide clinical practice. The objective is to compare the effect of general anesthesia (GA) and monitored anesthesia care (MAC) on clinical outcomes in patients with endovascular therapy for vertebrobasilar occlusion stroke. 139 patients undergoing endovascular therapy for vertebrobasilar stroke, were recruited. The patients were randomized into GA group and MAC group (about 11 ratio). GA group received general anesthesia and MAC group received monitored anesthesia care during endovascular therapy. T