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Female Wistar rats had been subjected to hypoxia (15 h/day) in a hypobaric hypoxic chamber (5500 m) for HP induction, whereas others had been held in sea level. These rats had been put through 45 min of hepatic ischemia by portal vein occlusion followed by 6 h of reperfusion. We evaluated HIF-1α in nuclear extracts, MnSOD, CuZnSOD, catalase, Bad/Bcl-xL/caspase 3/poly-(ADP-ribose)-polymerase (PARP), mitochondrial Bcl-xL, and cytosolic cytochrome C phrase with Western blot and nitroblue tetrazolium/3-nitrotyros
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