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The prospective analyses showed that patients in the subgroup of "mild depression" and "amnestic depression" had the highest remission rates, while patients in both frail-depressed subgroups had the highest mortality rates. Conclusions Late-life depression can be subtyped by specific combinations of age-related clinical features, which seems to have prospective relevance. Subtyping according the cognitive profile and physical frailty may be relevant for studies examining underlying disease processes as well as to stratify treatment studi

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