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Additionally, the expression levels of genes involved in synapse and antioxidant activity were downregulated in hippocampus of 3xTg mice at 9 months old compared with age-matched wild-type mice, which were suppressed by betaine intake. Betaine may be applicable as an agent preventing the progression of AD by improving the synaptic structure/function and/or antioxidant activity. Betaine may be applicable as an agent preventing the progression of AD by improving the synaptic structure/function and/or antioxidant activity. The most importa

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