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Adult ADHD and Comorbid Disorders Many adults with ADHD also have comorbid disorders like major depression (Kessler and colleagues, 2006). Many depressed patients aren't able to take medication and may be able to benefit from therapy. Treatments that are most effective in reducing core symptoms of ADHD seem to boost and balance levels of specific neurotransmitters in the brain. The most frequently prescribed stimulants include amphetamine,
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