https://www.selleckchem.com/pr....oducts/AR-42-HDAC-42
iTRAQ-based quantitative proteomic analysis revealed that VWCE overexpression induced a 10-fold decrease in the level of WD-repeat domain 1 (WDR1) protein expression. Rescue experiments further verified that WDR1 was a downstream molecule of VWCE, and WDR1 overexpression reversed the above effects of VWCE overexpression on tumor growth. Therefore, may represent a novel tumor suppressor, for which its deregulation promotes breast cancer progression via the upregulation of WDR1.Cancer remains one of the leading causes of death world
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