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001), whilst GFAP+ stellate astrocytes significantly decreased (p less then 0.001). Cellular reactions could be grouped into two distinct patterns an immune response associated with MHC-II/IBA1 expression and CD astrocytes; and a more innate response characterised by CD68 expression associated with WML. White matter neuroinflammation showed weak relationships to the measures of SVD, but not to the measures of AD neuropathology. In conclusion, glial responses vary extensively across the PARWM with diverse patterns of white matter neuroi

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