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signaling pathway.The translational potential of this article Our results provide a biological rationale for the use of losartan as a potential candidate for OA treatment. Krüppel like factor 10 (KLF1, which is also known as TGF-β Inducible Early Gene-1 (TIEG1), plays a crucial role in regulating cell proliferation, cell apoptosis and inflammatory reaction in human carcinoma cells. Moreover, KLF10 knockout in mice leads to severe defects associated with muscle, skeleton and heart etc. However, the function of KLF10 in intervertebral d
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