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These determinations underscore the critical impingement of AGEs on collagen fibril physicochemical properties , tendering perceptivitys into pathophysiological mechanical and biochemical alterations with significances for cell mechanotransduction during aging and in diabetes . STATEMENT OF SIGNIFICANCE : Collagen filaments are susceptible to glycation , the irreversible reaction of amino acids with sugars . Glycation affects the mechanical properties and surface alchemy of collagen fibrils with